A timely question given the recent popularity of these drugs: could semaglutide be associated with a risk of suicidal ideation?"Negative results are tricky, however. You can conclude that no relationship was evident from these data — which is the case here — but it's harder to conclude that there is no risk whatsoever.""For now, the weight of evidence does not suggest a major risk here. But it's not a bad idea to remember, whether prescribing these drugs or taking them, that they do affect the brain — that is how they work [crossing the blood-brain barrier]— and to be on the lookout for any changes, positive or negative, that might result from that interaction."#MentalHealth #LifestyleMedicine #epi #PublicHealth #preventionsummary article: https://lnkd.in/dbga9VPHprimary source, JAMA abstract: https://lnkd.in/d6HMzgAHprimary source, Nature Medicine article: https://lnkd.in/dHq-tCbH